Adverse drug events (ADEs) are a serious health issue in the United States. About 82% of American adults take at least one medication while 29% take ﬁve or more. ADEs lead to 700,000 emergency room visits, 120,000 hospitalizations and 100,000 deaths in the US each year. This results in over $30 billion in additional spend annually. 1
Pharmacogenomics studies have shown that more than 50% of the patient population are dosing ineﬀectively due at least in part to a genetic mismatch between the patient’s metabolism and the medication. Recent genetic research has helped to create a better understanding of this mismatch by explaining the signiﬁcance of genetics in drug metabolism.
This information about a patient’s genetic makeup, coupled with their lifestyle behavior and other risk factors, enhances the physician’s ability to provide personalized medical care and treatment to each patient.